Transmembrane Protein 3D Structures - Predicted by Evolutionary Couplings

Prediction results of individual protein domains that have UNKNOWN structures

Evolutionary couplings and 3D folds for membrane proteins that have unknown 3D structures.

Top # is the number of evolutionary constrains used and model number of blind top-ranked and best-generated model, respectively.

Meff is the effective number of sequences in the alignment after weighting by the number of sequences with sequence identity above a similarity threshold.

Uniprot ID PFAM TM Helices Modeled Length E-Value Meff Seq/Len Top Randked Model Download link
ADR1_HUMAN PF03006 7 375 40 1061 2.84 200-19 download_results
NU1M_HUMAN* PF00146 8 318        
S22A4_HUMAN* PF00083 12 551        
ABCG2_HUMAN PF01061 7 335 30 6358 19 230-3 download_results
ELOV4_HUMAN PF01151 7 314 10 1943 6.21 230-6 download_results
SL9A1_HUMAN PF00999 13 471 30 5519 11.71 190-10 download_results
MSMO1_HUMAN PF04116 5 264 10 5097 19 190-8 download_results
S13A1_HUMAN PF00939 15 396 20 5388 13.6 210-7 download_results
EAMA_ECOLI PF00892 10 299 30 22241 74.4 170-8 download_results
LIVH_ECOLI PF02653 8 308 30 11853 38.5 270-12 download_results
GABR1_HUMAN PF00003 7 311 10 2613 8.4 120-4 download_results
B1B3L4_STAAU PF05569 6 349 30 2307 6.6 120-7 download_results
CCG1_HUMAN PF04193 4 222 10 2963 13.3 170-2 download_results
CTNS_HUMAN PF05569 7 268 5 4019 15 230-3 download_results
NAC1_HUMAN* PF01699 5 211        
S5A1_HUMAN PF02544 7 220 10 6836 31.1 160-9 download_results
TSPOA_HUMAN* PF03073 5 169        
VIAAT_HUMAN PF01490 11 414 15 19260 46.5 380-19 download_results

* How did we do?

Four of the predictions from 2012 paper have now been solved experimentally.

Click here for comparisons of computed to experimentally determined structures.
Click here for the prediction results table from the 2012 paper.